Seminars in Orthodontics
Volume 14, Issue 2 , Pages 115-124 , June 2008

Investigation of Genetic Factors Affecting Complex Traits Using External Apical Root Resorption as a Model

  • Shaza K. Abass

      Affiliations

    • Assistant Professor of Dental Science, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan
  • ,
  • James K. Hartsfield Jr.

      Affiliations

    • Professor and Director of Oral Facial Genetics, Professor of Orthodontics, Indiana University School of Dentistry, Professor of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN.
    • Corresponding Author InformationAddress correspondence to James K. Hartsfield, Jr., DMD, PhD, Department of Orthodontics and Oral Facial Genetics, Indiana University School of Dentistry, 1121 W. Michigan St., Indianapolis, IN 46202-5186. Phone: 317-278-1148

References 

  1. Harris EF, Robinson QC, Woods MA. An analysis of causes of apical root resorption in patients not treated orthodontically. Quintessence Int. 1993;24:417–428
  2. Taithongchai R, Sookkorn K, Killiany DM. Facial and dentoalveolar structure and the prediction of apical root shortening. Am J Orthod Dentofacial Orthop. 1996;110:296–302
  3. Killiany DM. Root resorption caused by orthodontic treatment: an evidence-based review of literature. Semin Orthod. 1999;5:128–133
  4. Becks H. Root resorptions and their relation to pathological bone formation, part 1: statistical data and roentgenographic aspects. Int J Orthod Oral Surg. 1936;22:445–482
  5. Reitan K. Some factors determining the evaluation of forces in orthodontics. Am J Orthod. 1957;43:32–45
  6. Newman WG. Possible etiologic factors in external root resorption. Am J Orthod. 1975;67:522–539
  7. Massler M, Perreault JG. Root resorption in the permanent teeth of young adults. J Dent Child. 1954;21:158–164
  8. Massler M, Malone AJ. Root resorption in human permanent teeth: a roentgenographic study. Am J Orthod. 1954;40:619–633
  9. Sameshima GT, Sinclair PM. Predicting and preventing root resorption: part II (Treatment factors). Am J Orthod Dentofacial Orthop. 2001;119:511–515
  10. Harris EF, Kineret SE, Tolley EA. A heritable component for external apical root resorption in patients treated orthodontically. Am J Orthod Dentofacial Orthop. 1997;111:301–309
  11. Chanock S, Wacholder S. One gene and one outcome? (No way). Trends Mol Med. 2002;8:266–269
  12. Martin N, Boomsma D, Machin G. A twin-pronged attack on complex traits. Nat Genet. 1997;17:387–392
  13. Ngan DC, Kharbanda OP, Byloff FK, et al. The genetic contribution to orthodontic root resorption: a retrospective twin study. Aust Orthod J. 2004;20:1–9
  14. Hartsfield JK, Everett ET, Al-Qawasmi RA. Genetic factors in external apical root resorption and orthodontic treatment. Crit Rev Oral Biol Med. 2004;15:115–122
  15. Nakagawa N, Kinosaki M, Yamaguchi K, et al. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun. 1998;253:395–400
  16. Al-Qawasmi RA, Hartsfield JK, Everett ET, et al. Genetic predisposition to external apical root resorption in orthodontic patients: linkage of chromosome-18 marker. J Dent Res. 2003;82:356–360
  17. Meisler MH. The role of the laboratory mouse in the human genome project. Am J Hum Genet. 1996;59:764–771
  18. Ehrlich J, Sankoff D, Nadeau JH. Synteny conservation and chromosome rearrangements during mammalian evolution. Genetics. 1997;147:289–296
  19. Nadeau JH, Dunn PJ. Genomic strategies for defining and dissecting developmental and physiological pathways. [review] Curr Opin Genet Dev. 1998;8:311–315
  20. Silver L. Mouse Genetics. New York: Oxford University Press; 1995;
  21. Grisel JE. Quantitative trait locus analysis. Alcohol Res Health. 2000;24:169–174
  22. Brudvik P, Rygh P. The initial phase of orthodontic root resorption incident to local compression of the periodontal ligament. Eur J Orthod. 1993;15:249–263
  23. Al-Qawasmi RA, Hartsfield JK, Everett ET, et al. Root resorption associated with orthodontic force in IL-1beta knockout mouse. J Musculoskelet Neuronal Interact. 2004;4:383–385
  24. Roberts WE, Hartsfield JK, Al-Qawasmi R, et al. Physiologic interaction of root resorption, remodeling, tooth movement and ankylosis. In:  Davidovitch Z,  Mah J,  Suthanarak S editor. Biological Mechanisms of Tooth Eruption, Resorption and Movement. Boston, MA: Harvard Society for the Advancement of Orthodontics; 2006;p. 191–198
  25. Al-Qawasmi RA, Hartsfield JK, Everett ET, et al. Root resorption associated with orthodontic force in inbred mice: genetic contributions. Eur J Orthod. 2006;28:13–19
  26. Abass S, Hartsfield JK Jr, Al-Qawasmi R, Everett ET, Foroud T, Roberts WE: Inheritance of susceptibility to root resorption associated with orthodontic force in mice. Am J Orthod Dentofacial Orthop. In press

PII: S1073-8746(08)00014-5

doi: 10.1053/j.sodo.2008.02.008

Seminars in Orthodontics
Volume 14, Issue 2 , Pages 115-124 , June 2008